The TRT Knowledge Center
Your evidence-based guide to understanding and optimizing your therapy. Researched by experts, written for you.
Explore Core Topics
Key Articles:
- 10 Common Symptoms of Low Testosterone in Men
- How to Get Diagnosed with Low Testosterone: A Step-by-Step Guide
- How Much Does TRT Cost? A Full Breakdown
Key Articles:
- Understanding Testosterone: Total, Free, and SHBG Explained
- What Are Normal Testosterone Levels by Age?
- The Role of Estrogen (Estradiol / E2) for Men on TRT
Key Articles:
- Injection Frequency: Why More Often Is Often Better
- Subcutaneous vs. Intramuscular: Which TRT Injection is Better?
- The Complete Guide to Using HCG with TRT
Key Articles:
- Managing High Hematocrit on TRT: A Practical Guide
- How to Manage High Estrogen (E2) on TRT
- Does TRT Cause Hair Loss? The Truth About DHT and Your Hair
Key Articles:
- TRT and Weight Loss: How Testosterone Helps You Lose Fat
- TRT for Muscle Gain: What to Realistically Expect
- The Impact of TRT on Mood, Anxiety, and Depression
Key Articles:
- TRT Nation Review: Is It the Right Choice for You?
- Hone Health Review: At-Home TRT Testing & Treatment
- Marek Health Review: A Comprehensive Optimization Approach
All Articles
10 Common Symptoms of Low Testosterone in Men
Feeling tired, irritable, or low on libido? Learn the top 10 symptoms of low testosterone and find out if getting diagnosed is your next step to feeling better.
How to Get Diagnosed with Low Testosterone: A Step-by-Step Guide
Learn the exact steps to get diagnosed for TRT, from the essential blood tests you need to finding the right doctor who understands hormone optimization.
How Much Does TRT Cost? A Full Breakdown
Wondering about the cost of TRT? We break down the price of clinics, medication, blood work, and insurance coverage to give you a clear monthly estimate.
Your First TRT Injection: A Step-by-Step Guide
Feeling nervous about your first shot? This guide walks you through preparing your dose and safe injection technique so you can proceed with confidence.
Understanding Testosterone: Total, Free, and SHBG Explained
Dive deep into the key markers of hormonal health. Learn what Total T, Free T, and SHBG mean and why Free Testosterone is what truly matters for how you feel.
What Are Normal Testosterone Levels by Age?
See charts showing average testosterone levels for men by age. Learn why aiming for an 'optimal' range is more important than being 'normal for your age'.
The Role of Estrogen (Estradiol / E2) for Men on TRT
Estrogen isn't the enemy. Learn why men need Estradiol (E2) for libido, mood, and health, and why managing the T:E2 ratio is critical for feeling your best.
Injection Frequency: Why More Often Is Often Better
Discover why splitting your dose into more frequent injections (twice a week, EOD) is the #1 strategy for stable hormone levels, fewer side effects, and feeling better.
Subcutaneous vs. Intramuscular: Which TRT Injection is Better?
Compare subcutaneous (SubQ) vs. intramuscular (IM) injections for TRT. Learn the pros and cons of each for stability, comfort, and ease of use.
The Complete Guide to Using HCG with TRT
Learn why HCG is often used with TRT to maintain fertility, testicular size, and downstream hormone production. Includes dosage and protocol info.
Testosterone Cypionate vs. Enanthate vs. Propionate
Understand the differences between the most common testosterone esters used in TRT, including cypionate, enanthate, and propionate.
Managing High Hematocrit on TRT: A Practical Guide
One of the most common side effects of TRT is a rise in hematocrit. Learn what it is, why it happens, and practical steps you can take to manage it effectively.
How to Manage High Estrogen (E2) on TRT
Experiencing high E2 symptoms like water retention or moodiness? Learn protocol adjustments and strategies to manage high estrogen without crashing it.
Does TRT Cause Hair Loss? The Truth About DHT and Your Hair
Worried about hair loss on TRT? Understand the connection between testosterone, DHT, and male pattern baldness, plus strategies to protect your hair.
What Happens When You Stop TRT? (A Guide to PCT)
Considering stopping TRT? Learn about the shutdown process and how a proper Post Cycle Therapy (PCT) protocol can help restart your natural production.
TRT and Weight Loss: How Testosterone Helps You Lose Fat
Learn the mechanisms behind how Testosterone Replacement Therapy aids in fat loss, boosts metabolism, and helps you build a leaner physique.
TRT for Muscle Gain: What to Realistically Expect
How much muscle can you actually gain on TRT? We break down the science of testosterone and muscle protein synthesis and what you can expect in the gym.
The Impact of TRT on Mood, Anxiety, and Depression
Explore the powerful connection between testosterone and mental well-being. Learn how TRT can improve mood, reduce anxiety, and lift brain fog.
TRT Nation Review: Is It the Right Choice for You?
Our in-depth TRT Nation review covers their process, pricing, customer service, and what real patients are saying. Is this budget clinic worth it?
Hone Health Review: At-Home TRT Testing & Treatment
We review Hone Health's at-home hormone testing and TRT treatment program. Explore their platform, costs, and the quality of their medical support.
Marek Health Review: A Comprehensive Optimization Approach
Marek Health offers more than just TRT. Our review dives into their comprehensive health optimization, diagnostic process, and premium pricing model.